2ND ADVANCED COURSE ON THE PHARMACOLOGICAL TREATMENT OF DRUG RESISTANT EPILEPSIES (DRE): FROM RARE TO COMMON EPILEPSIES

Friday, 8th November

DEFINITION AND EPIDEMIOLOGY

16:15 h - 16:30 h

Welcome and Introduction

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
Torbjörn Tomson. Department of Clinical Neuroscience, Karolinska Institutet. Stockholm, Sweden
Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany
16:30 h - 17:00 h

Concept, Epidemiology and social impact of DRE

Eugen Trinka. Paracelsus University. Salzburg, Austria
17:00 h - 17:30 h

Other impact of DRE: Mortality and SUDEP

Torbjörn Tomson. Department of Clinical Neuroscience, Karolinska Institutet. Stockholm, Sweden
17:30 h - 18:00 h

Pseudo-DRE: Concept and diagnosis

Torbjörn Tomson. Department of Clinical Neuroscience, Karolinska Institutet. Stockholm, Sweden
18:00 h - 19:00 h

Cases: Difficult to diagnose DRE

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
Torbjörn Tomson. Department of Clinical Neuroscience, Karolinska Institutet. Stockholm, Sweden
Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany
Chairman: Manuel Toledo Argany
Saturday, 9th November

BASIC MECHANISMS AND PREDICTORS

08:30 h - 09:00 h

Basic mechanisms

Heidrun Potschka. Ludwig-Maximilians-University. Munich, Germany
09:00 h - 09:30 h

Can we predict DRE in the focal epilepsies?

Mar Carreño. Hospital Clinic , Barcelona

PHARMACOLOGICAL OPTIONS

09:30 h - 10:00 h

Break

10:00 h - 10:30 h

Pharmacokinetic interactions between ASMs used in polytherapy

Cecilie Johannessen Landmark. Oslo University Hospital, Oslo, Norway
10:30 h - 11:00 h

Rational polytherapy V.2024. Interactions of third generation ASM.

Andres M Kanner. University of Miami Miller School of Medicine. USA
11:00 h - 11:30 h

Overtreatment vs therapeutic nihilism

Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany
11:30 h - 12:30 h

Cases: Polytherapy and interactions

Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany
Andres M Kanner. University of Miami Miller School of Medicine. USA
Cecilie Johannessen Landmark. Oslo University Hospital, Oslo, Norway
Chairman: Manuel Toledo Argany
12:30 h - 13:00 h

Symposium 1 - Jazz Pharmaceuticals

13:00 h - 14:00 h

Lunch

17:30 h - 18:00 h

Symposium 2 - Angelini Pharma

FUTURE ASMs AND THERAPIES

14:00 h - 14:30 h

ASMs close to launching and future strategies

Meir Bialer. Institute for Drug Research, School of Pharmacy and David R. Bloom Centre for Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem. Jerusalem, Israel
14:30 h - 15:00 h

Advanced therapies

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
15:00 h - 15:30 h

RNA therapies

Felix Rosenow. Epilepsy Center Frankfurt Rhine-Main. Center of Neurology and Neurosurgery, Goethe-University Frankfurt. Frankfurt, Germany
15:30 h - 16:00 h

Break

IDIOPATHIC GENERALIZED EPILEPSIES (IGEs)

16:00 h - 16:30 h

Drug resistant IGEs: clinical characteristics

Javier Salas Puig. Hospital Universitario Vall d'Hebron. Barcelona, Spain
16:30 h - 17:00 h

Treatment of drug resistant IGEs

Guido Rubboli. Institute of Clinical Medicine, University of Copenhagen, Danish Epilepsy Center, Dianalund, Denmark
Sunday, 10th November

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHIES (DEEs)

08:30 h - 09:00 h

Clinical characteristics of the main types of DEEs

Elena Gardella. Danish Epilepsy Center and University of Southern Denmark. Dianalund, Denmark
09:00 h - 09:30 h

Treatment of Dravet disease and Lennox-Gastaut syndrome

Stephan Auvin. Robert Debré Hospital, Public Hospital Network of Paris. Paris, France
09:30 h - 10:00 h

Treatment of other DEEs: CDKL5, KNQ2, SCN8A, SCN2A, DEPDC5

10:00 h - 10:30 h

Break

10:30 h - 11:30 h

Cases: DEEs

Stephan Auvin. Robert Debré Hospital, Public Hospital Network of Paris. Paris, France
Elena Gardella. Danish Epilepsy Center and University of Southern Denmark. Dianalund, Denmark
Chairman: Manuel Toledo Argany
11:30 h - 12:00 h

Symposium 3 - UCB Pharma

SPECIAL LECTURE

12:00 h - 12:15 h

Outcome measures in DRE clinical trials

Jacqueline French. NYU Grossman School of Medicine. New York, USA
12:15 h - 12:45 h

Comprehensive evaluation test

12:45 h - 13:00 h

Conclusions

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
Torbjörn Tomson. Department of Clinical Neuroscience, Karolinska Institutet. Stockholm, Sweden
Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany